1-甲基吲哚-2-羧酸乙酯合成路线 （共 25 条）
反应条件
sulfuric acid
24 h; Heating;
参考文献
Daou, Boujemaa; Soufiaoui, Mohamed
Tetrahedron, 1989 , vol. 45, # 11 p. 3351 - 3362
反应条件
hydrogenchloride in ethanol
0.333333 h; Heating; Further byproducts given. Yields of byproduct given;
参考文献
Ishii; Murakami; Ishikawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 597 - 604
反应条件
1: 95 percent / conc. H2SO4 / 18 h / Heating
2: K2SO4
View Scheme
参考文献
Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
反应条件
1: 80 percent / trifluoroacetic acid / H2O; CCl4 / 2.5 h / 0 °C
View Scheme
参考文献
Masters, N. F.; Mathews, N.; Nechvatal, G.; Widdowson, D. A.
Tetrahedron, 1989 , vol. 45, # 18 p. 5955 - 5970
反应条件
1: hydrogenchloride; sodium nitrite; tin(ll) chloride / -5 - 20 °C
2: acetic acid / ethanol / 1 h / 80 °C
3: polyphosphoric acid / toluene / 5 h / 100 °C
4: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C
View Scheme
参考文献
Panathur, Naveen; Dalimba, Udayakumar; Koushik, Pulla Venkat; Alvala, Mallika; Yogeeswari, Perumal; Sriram, Dharmarajan; Kumar, Vijith
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 125 - 138
反应条件
1: acetic acid / ethanol / 1 h / 80 °C
2: polyphosphoric acid / toluene / 5 h / 100 °C
3: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C
View Scheme
参考文献
Panathur, Naveen; Dalimba, Udayakumar; Koushik, Pulla Venkat; Alvala, Mallika; Yogeeswari, Perumal; Sriram, Dharmarajan; Kumar, Vijith
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 125 - 138
反应条件
1: polyphosphoric acid / toluene / 5 h / 100 °C
2: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C
View Scheme
参考文献
Panathur, Naveen; Dalimba, Udayakumar; Koushik, Pulla Venkat; Alvala, Mallika; Yogeeswari, Perumal; Sriram, Dharmarajan; Kumar, Vijith
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 125 - 138
反应条件
Yield given. Multistep reaction;
参考文献
Masters, N. F.; Mathews, N.; Nechvatal, G.; Widdowson, D. A.
Tetrahedron, 1989 , vol. 45, # 18 p. 5955 - 5970
反应条件
hydrogenchloride in ethanol
0.333333 h; Heating; Product distributionMechanism;
参考文献
Ishii; Murakami; Ishikawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 597 - 604
反应条件
1: 65 percent / NH2OH / methanol / 2 h / Ambient temperature
2: 70 percent / HCl(g) / ethanol / Ambient temperature
View Scheme
参考文献
Kogan, N. A.; Ivanov, V. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 2 p. 188 - 190
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 2 p. 227 - 229
