3-羟基-3-甲基丁酸乙酯合成路线 （共 20 条）
反应条件
durch Wasserabspaltung und Verseifung des Reaktionsprodukts;
参考文献
Friedmann
B.Ph.P., 1908 , vol. 11, p. 374
反应条件
phosphorus trichoride
参考文献
Machleidt,H. et al.
Justus Liebigs Annalen der Chemie, 1963 , vol. 667, p. 35 - 47
参考文献
Schinz; Hinder
Helvetica Chimica Acta, 1947 , vol. 30, p. 1349,1366
反应条件
in toluene T=206°C; deuterium isotope effects in the thermal decomposition; Rate constant;
参考文献
Quijano, Jairo; Restrepo, Iliana; Gallego, Luis H.; Yepes, M. del Socorro
Tetrahedron Letters, 1994 , vol. 35, # 27 p. 4735 - 4738
反应条件
in diethyl ether Heating;
参考文献
Philaja,K.; Ketola,M.
Acta Chemica Scandinavica (1947-1973), 1969 , vol. 23, p. 715 - 726
反应条件
lithium aluminium tetrahydride
参考文献
Virtanen, Terttu; Nikander, Hannu
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 2 p. 113 - 116
反应条件
1: ethyl acetate With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h; Inert atmosphere;
2: acetone in tetrahydrofuran
0.166667 h;
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; BRANDHUBER, Barbara J.; CONDROSKI, Kevin Ronald; HUANG, Lily; KERCHER, Timothy; WINSKI, Shannon L.
Patent: WO2014/78408 A1, 2014 ;
Location in patent: Paragraph 00558 ;
反应条件
silver; zinc in tetrahydrofuran; diethyl ether
Heating;
参考文献
Bortolussi, Michel; Seyden-Penne, Jacqueline
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2355 - 2362
反应条件
toluene-4-sulfonic acid in cyclohexane
T=85°C; 5 h; Molecular sieve; Reagent/catalystSolvent;
参考文献
Cheong, Ling-Zhi; Widzisz, Katarzyna; Wang, Yingyao; Jensen, Henrik Helligso; Theil, Peter Kappel; Guo, Zheng; Xu, Xuebing
JAOCS, Journal of the American Oil Chemists' Society, 2013 , vol. 90, # 6 p. 919 - 922
参考文献
Gresham et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 486
