4-羟基-3-苯基香豆素合成路线 （共 31 条）
反应条件
in dichloromethane
16 h; Heatingdark;
参考文献
Barton; Donnelly; Finet; Stenson
Tetrahedron, 1988 , vol. 44, # 20 p. 6387 - 6396
反应条件
pyridine in chloroform
T=60°C; 16 h;
参考文献
Barton, Derek H. R.; Donnelly, Dervilla M. X.; Finet, Jean-Pierre; Guiry, Patrick J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , p. 1365 - 1376
反应条件
potassium hydride in tetrahydrofuran
67 h; Heating;
参考文献
Barton; Donnelly; Finet; Stenson
Tetrahedron, 1988 , vol. 44, # 20 p. 6387 - 6396
反应条件
in diphenylether
T=270°C; 0.5 h; Further byproducts given;
参考文献
Sardesai, Lina G.; Paknikar, Shashikumar K.; Bates, Robert B.; Siahaan, Teruna J.; Kane, Vinayak V.; Mishra, Prasana K.
Heterocycles, 1987 , vol. 26, # 11 p. 2941 - 2944
反应条件
1: 94 percent / CH2Cl2 / 20 °C
2: 10 percent / Na2Te / tetrahydrofuran / -20 - 20 °C
View Scheme
参考文献
Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686
参考文献
Sardesai, Lina G.; Paknikar, Shashikumar K.; Bates, Robert B.; Siahaan, Teruna J.; Kane, Vinayak V.; Mishra, Prasana K.
Heterocycles, 1987 , vol. 26, # 11 p. 2941 - 2944
反应条件
1: 1) BuLi, 2) ZnCl2, 3) PdCl2(PPh3)2, DIBAL-H / 1) THF, -78 deg C, 2) THF, -78 deg C, 3) THF, 0 deg C to RT
2: 93 percent / NaH / tetrahydrofuran / Heating
3: 86 percent / TFA / toluene / 1 h / Heating
View Scheme
参考文献
Kalinin, Alexey V.; Da Silva, Alcides J. M.; Lopes, Claudio C.; Lopes, Rosangela S. C.; Snieckus, Victor
Tetrahedron Letters, 1998 , vol. 39, # 28 p. 4995 - 4998
反应条件
1: 1) BuLi, 2) ZnCl2, 3) PdCl2(PPh3)2, DIBAL-H / 1) THF, -78 deg C, 2) THF, -78 deg C, 3) THF, 0 deg C to RT
2: 93 percent / NaH / tetrahydrofuran / Heating
3: 86 percent / TFA / toluene / 1 h / Heating
View Scheme
参考文献
Kalinin, Alexey V.; Da Silva, Alcides J. M.; Lopes, Claudio C.; Lopes, Rosangela S. C.; Snieckus, Victor
Tetrahedron Letters, 1998 , vol. 39, # 28 p. 4995 - 4998
反应条件
1: 93 percent / NaH / tetrahydrofuran / Heating
2: 86 percent / TFA / toluene / 1 h / Heating
View Scheme
参考文献
Kalinin, Alexey V.; Da Silva, Alcides J. M.; Lopes, Claudio C.; Lopes, Rosangela S. C.; Snieckus, Victor
Tetrahedron Letters, 1998 , vol. 39, # 28 p. 4995 - 4998
反应条件
in diphenylether
T=270°C; 0.5 h; Further byproducts given;
参考文献
Sardesai, Lina G.; Paknikar, Shashikumar K.; Bates, Robert B.; Siahaan, Teruna J.; Kane, Vinayak V.; Mishra, Prasana K.
Heterocycles, 1987 , vol. 26, # 11 p. 2941 - 2944
