1-(金刚烷-1-基)-1-丙酮合成路线 （共 17 条）
反应条件
aluminium trichloride; copper(l) chloride; lithium chloride in tetrahydrofuran; diethyl ether T=10°C; 0.166667 h;
参考文献
Vicha, Robert; Potacek, Milan
Tetrahedron, 2005 , vol. 61, # 1 p. 83 - 88
反应条件
1: N-cyclohexyladamantane-1-carboxamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 20°C; Inert atmosphere; 2: ethylmagnesium bromide in dichloromethane T=-78°C; 0.416667 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane T=65°C; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Bechara, William S.; Pelletier, Guillaume; Charette, Andre B.
Nature Chemistry, 2012 , vol. 4, # 3 p. 228 - 234
反应条件
in diethyl ether; benzene 38 h; Ambient temperature;
参考文献
Heathcock, Clayton H.; Buse, Charles T.; Kleschick, William A.; Pirrung, Michael C.; Sohn, John E.; Lampe, John
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1066 - 1081
反应条件
1: ethyl bromide With magnesium in diethyl ether 2: adamantane-1-carbonyl chloride in diethyl ether T=20°C; 48 h; Further stages. Further byproducts.;
参考文献
Vicha, Robert; Necas, Marek; Potacek, Milan
Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 5 p. 709 - 722
反应条件
copper(l) chloride in diethyl ether 1 h; Heating;
参考文献
Grava, I. Ya.; Polis, Ya. Yu.; Lidak, M. Yu.; Liepin'sh, E. E.; Shatts, V. D.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 4 p. 679 - 686
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 4 p. 778 - 786
反应条件
1.1: 89 percent / SOCl2 / toluene / 8 h / 70 °C 2.1: Mg / diethyl ether 2.2: diethyl ether / 48 h / 20 °C View Scheme
参考文献
Vicha, Robert; Potacek, Milan
Tetrahedron, 2005 , vol. 61, # 1 p. 83 - 88
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in 1,4-dioxane 14 h; Inert atmosphereReflux;
参考文献
Averin; Ulanovskaya; Buryak; Savel'ev; Orlinson; Novakov; Beletskaya
Russian Journal of Organic Chemistry, 2010 , vol. 46, # 12 p. 1790 - 1811
反应条件
in diethyl ether 3 h; Heating;
参考文献
Dermugin, V. S.; Shvedov, V. I.; Litvinov, V. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, # 11 p. 2362 - 2366
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 11 p. 2549 - 2554
反应条件
1: 83 percent / Ag2CO3/Celite / benzene / 0.67 h / 110 - 120 °C 2: 63 percent / benzene; pentane / Heating 3: 4 percent / TsOH*H2O, AcOH / 0.5 h / Heating View Scheme
参考文献
Takeuchi; Yoshida; Nishida; Kohama; Kitagawa
Synthesis, 1991 , # 1 p. 37 - 40
反应条件
1: 47 percent / pyridine, TsCl / 1) 40 h, r.t. 2) reflux, 2 h 2: 83 percent / Ag2CO3/Celite / benzene / 0.67 h / 110 - 120 °C 3: 63 percent / benzene; pentane / Heating 4: 4 percent / TsOH*H2O, AcOH / 0.5 h / Heating View Scheme
参考文献
Takeuchi; Yoshida; Nishida; Kohama; Kitagawa
Synthesis, 1991 , # 1 p. 37 - 40
