1alpha,3alpha-环戊烷二醇合成路线 （共 7 条）
反应条件
tri-ruthenium(0)dodecacarbonyl; 4,5-bis-(di-isopropylphosphinomethyl)acridine; ammonia in 1,1-dimethylpropan-1-ol T=170°C; 21 h; Inert atmosphereSchlenk techniqueAutoclave; Temperature;
参考文献
Pingen, Dennis; Diebolt, Olivier; Vogt, Dieter
ChemCatChem, 2013 , vol. 5, # 10 p. 2905 - 2912
反应条件
benzyltrichlorostannane T=95 - 115°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Marton, Daniele; Slaviero, Pierangelo; Tagliavini, Giuseppe
Tetrahedron, 1989 , vol. 45, # 22 p. 7099 - 7108
反应条件
tri-ruthenium(0)dodecacarbonyl; 4,5-bis-(di-isopropylphosphinomethyl)acridine; ammonia in 1,1-dimethylpropan-1-ol T=170°C; 21 h; Inert atmosphereSchlenk techniqueAutoclave; Temperature;
参考文献
ChemCatChem, , vol. 5, # 10 p. 2905 - 2912
反应条件
benzyltrichlorostannane T=95 - 115°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 45, # 22 p. 7099 - 7108
反应条件
1: cis-cyclopentane-1,3-diol With (4S)-4-isopropyl-2-methoxy-3-((R)-2-methyl-1-(1-methyl-1H-imidazol-2-yl)propyl)oxazolidine; Pempidine hydrochloride in tetrahydrofuran
T=20°C; 0.166667 h; Inert atmosphere;
2: tert-butyldimethylsilyl chloride With N-methyl-2,2,6,6-tetramethylpiperidine in tetrahydrofuran
T=20°C; 4 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Manville, Nathan; Alite, Hekla; Haeffner, Fredrik; Hoveyda, Amir H.; Snapper, Marc L.
Nature Chemistry, 2013 , vol. 5, # 9 p. 768 - 776
反应条件
(S)-N-((R)-3,3-dimethylbutan-2-yl)-3,3-dimethyl-2-(((1-methyl-1H-imidazol-2-yl)methyl)amino)butanamide; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=-78°C; 48 h; enantioselective reaction;
参考文献
Manville, Nathan; Alite, Hekla; Haeffner, Fredrik; Hoveyda, Amir H.; Snapper, Marc L.
Nature Chemistry, 2013 , vol. 5, # 9 p. 768 - 776
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US6013827 A1, 2000 ;
US 6013827 A
