(4S,5R)-(-)-4-甲基-5-苯基-2-噁唑烷酮合成路线 （共 28 条）
反应条件
1: 62 percent / Et3SiH, CF3COOH / 0 °C 2: 65 percent / 7.5 N KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 50 p. 6331 - 6334
反应条件
1: diethyl ether 2: 62 percent / Et3SiH, CF3COOH / 0 °C 3: 65 percent / 7.5 N KOH / tetrahydrofuran; methanol / 3 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 50 p. 6331 - 6334
反应条件
copper(l) iodide; chloro-trimethyl-silane; zinc(II) chloride; zinc in diethyl ether 22 h; Inert atmosphereReflux; diastereoselective reaction;
参考文献
European Journal of Organic Chemistry, , # 10 p. 1532 - 1548
反应条件
1: 88 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 2: NaBH4 / tetrahydrofuran; H2O / 6 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 14 p. 3896 - 3904
反应条件
1: 84 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 2: NaBH4 / tetrahydrofuran; H2O / 6 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 14 p. 3896 - 3904
反应条件
1: BF3*OEt2 / CH2Cl2 / 24 h / -40 °C 2: 78 percent / aq. HCl / acetonitrile / 5 h / 20 °C 3: 88 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 4: NaBH4 / tetrahydrofuran; H2O / 6 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 14 p. 3896 - 3904
反应条件
1: 78 percent / aq. HCl / acetonitrile / 5 h / 20 °C 2: 88 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 3: NaBH4 / tetrahydrofuran; H2O / 6 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 14 p. 3896 - 3904
反应条件
1: 72 percent / aq. HCl / acetonitrile / 5 h / 20 °C 2: 84 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 3: NaBH4 / tetrahydrofuran; H2O / 6 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 14 p. 3896 - 3904
