3-(三甲基甲硅烷基)丙酸乙酯合成路线 （共 14 条）
反应条件
1: propynoic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphereLarge scale reaction; 2: chloro-trimethyl-silane in tetrahydrofuran; hexane T=-78 - 20°C; 1.33333 h; Inert atmosphere;
参考文献
Kloss, Florian; Koehn, Uwe; Jahn, Burkhard O.; Hager, Martin D.; Goerls, Helmar; Schubert, Ulrich S.
Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2816 - 2824
参考文献
Cossy; Schmitt; Cinquin; Buisson; Belotti
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1699 - 1700
反应条件
1: (E)-3-iodo-prop-2-enoic-acid ethyl ester With copper(l) iodide; bis (triortho-tolylphosphine)palladium(II) chloride; triethylamine T=50°C; Sonogashira Cross-Coupling; 2: trimethylsilylacetylene T=50°C; Sonogashira Cross-Coupling; 12 h;
参考文献
Candy, Mathieu; Tomas, Loic; Parat, Sabrina; Heran, Virginie; Bienayme, Hugues; Pons, Jean-Marc; Bressy, Cyril
Chemistry - A European Journal, 2012 , vol. 18, # 45 p. 14267 - 14271
反应条件
thionyl chloride beim anschliessenden Behandeln mit Aethanol;
反应条件
n-butyllithium 1) diethyl ether, hexane, 48 h, reflux, 2) diethyl ether, hexane, -20 deg C; 12 h., r.t.; Yield given. Multistep reaction;
参考文献
Chemische Berichte, , vol. 116, # 10 p. 3309 - 3315
反应条件
potassium carbonate in N,N-dimethyl-formamide T=15 - 25°C; 4.16667 h;
参考文献
WO2012/116217 A1, ;
Page/Page column 103 ;
WO 2012/116217 A1
反应条件
in methanol T=-50°C;
参考文献
Medvedeva, A. S.; Demina, M. M.; Kalikhman, I. D.; Kositsyna, E. I.; Vyazankin, N. S.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 2 p. 468 - 471,409 - 411
反应条件
AgCl; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=50°C; 12 h;
参考文献
Lecercle, Delphine; Mothes, Celine; Taran, Frederic
Synthetic Communications, 2007 , vol. 37, # 8 p. 1301 - 1311
反应条件
in diethyl ether 4 h;
参考文献
Safronova, L. P.; Medvedeva, A. S.; Vyazankin, N. S.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 6 p. 1313 - 1315,1177 - 1179
