1: 4-amino-benzoic acid With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: acetylacetone With sodium acetate in methanol; water
T=0 - 20°C; 1 h;
sodium hydrogencarbonate in 1,4-dioxane; water
16 h;
参考文献
Vernall, Andrea J.; Stoddart, Leigh A.; Briddon, Stephen J.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1771 - 1782