1-乙氧羰基吡咯烷-3-酮合成路线 （共 14 条）
反应条件
1: N-(ethoxycarbonyl)-α-amino methyl carboxylic ester With sodium hydride in benzene T=20°C; 16 h; Reflux; 2: acrylic acid methyl ester in benzene Michael condensation; 8 h; Reflux;
参考文献
PURDUE RESEARCH FOUNDATION; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH and HUMAN SERVICES
Patent: WO2009/140467 A1, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
hydrogenchloride Decarboxylation; 4 h; Heating;
参考文献
Yadav; Sarkar, Sanjita; Chandrasekhar
Tetrahedron, 1999 , vol. 55, # 17 p. 5449 - 5456
反应条件
oxalic acid in 1,4-dioxane T=100°C; Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 15 p. 1047 - 1048
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 12 p. 3219 - 3223
反应条件
sulfuric acid; sodium ethanolate Multistep reaction;
参考文献
Heterocycles, , vol. 19, # 9 p. 1605 - 1607
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 48, # 21 p. 3644 - 3648
参考文献
Fujimori, Kunihide; Fukazawa, Hiroyuki; Nezu, Yasuhiko; Yamane, Kameji; Yasunami, Masafumi; Takase, Kahei
Chemistry Letters, 1986 , p. 1021 - 1024
反应条件
hydrogenchloride; water T=110 - 115°C;
参考文献
Angewandte Chemie, , vol. 69, p. 60
反应条件
lithium aluminium tetrahydride
参考文献
Kuhn; Osswald
Angewandte Chemie, 1957 , vol. 69, p. 60
参考文献
Kuhn; Osswald
Angewandte Chemie, 1957 , vol. 69, p. 60
