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(i) NaHSO3, H2O, (ii) /BRN= 3587243/; Multistep reaction;
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1: 2-chloro-5-(hydroxymethyl)pyridine With methanesulfonyl chloride; triethylamine in dichloromethane T=-78 - 0°C; 1 h; 2: With hydrogenchloride in dichloromethane; water pH=4; 3: sodium cyanide in DMF (N,N-dimethyl-formamide) T=20°C; 3 h;
参考文献
MERCK FROSST CANADA and CO.
Patent: WO2005/56529 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/056529 A1
in dimethyl sulfoxide T=20°C; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
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