1: 1) DMAP, Et3N, 2) gl. acetic acid, TFE / 2) CH2Cl2, 0 deg C 2: aq. NaOH / dioxane; H2O View Scheme

sodium hydroxide in 1,4-dioxane; water Yield given;

in 1,4-dioxane; water Yield given;

trifluoroacetic acid in dichloromethane 0.0833333 h; Ambient temperatureO-Trt-deprotection of N-Fmoc-Ser(Trt)-OH or N-Fmoc-Tyr(Trt)-OH; or with gl. acetic acid/ TFE/H2CCl2 (1:1:8);

1: 84 percent / CH2Cl2; tetrahydrofuran / 20 °C 2: 94 percent / trifluoroacetic acid; triisopropylsilane / CH2Cl2 / 1 h / 20 °C View Scheme

1: N-Fmoc-D-Tyr(t-Bu)-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine TentaGel RRAM solid phase resin; 2: With piperidine in N,N-dimethyl-formamide T=50°C; 1 h; 3: N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; N-(9H-fluoren-9-ylmethyloxycarbonylamino)-L-alanine; Fmoc–Pro–OH; Fmoc-L-phenylalanine; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; Fmoc-O-trityl-l-threonine; fmoc-Asn(trt)-OH; fmoc-Gln(Trt)-OH; Nα-Fmoc-N(im)-trityl-L-histidine; Fmoc-Asp(OMpe)-OH; N-(9-fluorenyl)methoxycarbonyl-Trp(Boc)-OH; fmoc-L-Arg(Pbf)-OH Further stages;