2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With tetrakis(dimethylamino)diboron; potassium acetate in toluene T=80°C; 0.5 h; 2: 2-methoxybromobenzene With tetrakis(triphenylphosphine) palladium(0) in toluene T=80°C; 22 h;
参考文献
BASF SE; SCHMIDT-LEITHOFF, Joachim; PICHLMAIR, Stefan; BELLO, Charles; BASF (CHINA) COMPANY LIMITED
Patent: WO2013/14579 A1, 2013 ;
Location in patent: Page/Page column 11; 12; 13 ;
反应条件
in toluene RefluxInert atmosphere;
参考文献
Berini, Christophe; Navarro, Oscar
Chemical Communications, 2012 , vol. 48, # 10 p. 1538 - 1540
反应条件
1: potassium acetate / 80 °C 2: tetrakis(triphenylphosphine) palladium(0) / toluene / 22 h / 80 °C View Scheme
参考文献
Bello, Charles S.; Schmidt-Leithoff, Joachim
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6230 - 6235,6
反应条件
sulfuric acid in toluene T=110°C; 16 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/103035 A1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine in benzene
参考文献
Majoral,J.-P.; Navech,J.
Bulletin de la Societe Chimique de France, 1971 , p. 95 - 104
反应条件
1: 72 percent / BF3*OEt2 / acetonitrile / 16 h / 20 °C 2: 85 percent / NaOH / tetrahydrofuran; H2O / 5 h / 20 °C View Scheme
参考文献
Wardrop, Duncan J.; Forslund, Raymond E.; Landrie, Chad L.; Velter, Adriana I.; Wink, Donald; Surve, Bushan
Tetrahedron Asymmetry, 2003 , vol. 14, # 7 p. 929 - 940
反应条件
in chloroform-d1 T=20°C; 894 h; Title compound not separated from byproducts.;
参考文献
Roy, Chandra D.; Brown, Herbert C.
Monatshefte fur Chemie, 2007 , vol. 138, # 9 p. 879 - 887
反应条件
1: tetrakis(dimethylamino)diboron; 3-hydroxy-2,2-dimethylpropanol With potassium acetate in toluene T=80°C; 2: 4-nitrophenyl trifluoromethanesulphonate With tetrakis(triphenylphosphine) palladium(0) in toluene T=80°C; 22 h;
参考文献
Tetrahedron Letters, , vol. 53, # 46 p. 6230 - 6235,6
反应条件
1: in cyclohexane 1.5 h; Heating / reflux; 2: With N-bromosuccinmide; dibenzoyl peroxide in cyclohexane 2 h; Heating / reflux;
参考文献
Dayagi, Yohai Y.; Dayan, Lev; Shalom, Moshe
Patent: US2007/117983 A1, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
1.1: n-BuLi / heptane; tetrahydrofuran / 0.75 h / -78 °C 1.2: B(Oi-Pr)3 / tetrahydrofuran; heptane / 2 h / -78 - -10 °C 1.3: 50 percent / acetic acid / tetrahydrofuran; heptane / -10 - 20 °C 2.1: 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione; AIBN / cyclohexane / 79 °C View Scheme
参考文献
Gorityala, Bala Kishan; Lu, Zhiqiang; Leow, Min Li; Ma, Jimei; Liu, Xue-Wei
Journal of the American Chemical Society, 2012 , vol. 134, # 37 p. 15229 - 15232
