2,4,5-三氟-3-甲氧基苯甲酸合成路线 （共 19 条）
参考文献
Asahi Glass Company Ltd.
Patent: US5523476 A1, 1996 ;
反应条件
sodium hydroxide in water
反应条件
sulfuric acid; sodium nitrite in water
反应条件
sodium hydroxide in methanol 3 h; Ambient temperature;
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
参考文献
Clariant GmbH
Patent: US5849959 A1, 1998 ;
反应条件
thionyl chloride 2 h; Reflux;
参考文献
Chen, Yin-Bo; Li, Ji-Ling; Shao, Xu-Sheng; Xu, Xiao-Yong; Li, Zhong
Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 673 - 676
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 24 h / 20 °C 2: 1.88 g / Et3N / toluene / 5 h / 90 °C 3: ethanol; diethyl ether / 3 h / 20 °C 4: 627 mg / K2CO3 / dimethylformamide / 5 h / 100 °C View Scheme
参考文献
Gomez, Catherine; Ponien, Prishila; Serradji, Nawal; Lamouri, Aazdine; Pantel, Alix; Capton, Estelle; Jarlier, Vincent; Anquetin, Guillaume; Aubry, Alexandra
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 948 - 956
反应条件
1.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C 2.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 2.2: hexane; tetrahydrofuran; CH2Cl2 / -78 - 10 °C View Scheme
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
反应条件
sulfuric acid 20 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1518856 A1, 2005 ;
Location in patent: Page/Page column 17 ;
反应条件
1.1: oxalyl chloride; N,N-dimethylformamide / CH2Cl2 / 1.5 h / 20 °C 1.2: 100 percent / ammonia gas / CH2Cl2 / 2 h / 0 °C 2.1: 1,2-dichloro-ethane / 4 h / Heating 2.2: 90 percent / dioxane / 4 h / 0 - 20 °C 3.1: 84 percent / potassium bis(trimethylsilyl)amide; 18-crown-6 / tetrahydrofuran; toluene / 1.5 h / Heating 4.1: 89 percent / sodium hydride; (2,4-dinitro-phenyl)-hydroxylamine / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Beylin, Vladimir; Boyles, David C.; Curran, Timothy T.; Macikenas, Dainius; Parlett IV, Roger V.; Vrieze, Derek
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 441 - 449
