S(-)-4-碘-3-羟基丁酸乙酯合成路线 （共 7 条）
反应条件
silver(l) oxide in acetonitrile Ambient temperature;
参考文献
Huang, Guangfei; Hollingsworth, Rawle I.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4113 - 4115
反应条件
in ethanol; water T=45°C; 3 h;
参考文献
Occhiato, Ernesto G.; Scarpi, Dina; Guarna, Antonio
European Journal of Organic Chemistry, 2008 , # 3 p. 524 - 531
反应条件
sodium iodide in acetone
T=58 - 60°C; 120 h;
参考文献
LEK Pharmaceuticals d.d.
Patent: EP1775299 A1, 2007 ;
Location in patent: Page/Page column 13; 16-17 ;
反应条件
trimethylsilyl iodide; 3 A molecular sieve in dichloromethane
T=20°C;
参考文献
Ensch, Corinne; Hesse, Manfred
Helvetica Chimica Acta, 2003 , vol. 86, # 1 p. 233 - 246
反应条件
D-glucose; broth E. coli HB101; pNTS1G; NADP in various solvent(s)
T=30°C; pH=6.5; 20 h; Enzymatic reaction;
参考文献
Yasohara, Yoshihiko; Kizaki, Noriyuki; Hasegawa, Junzo; Wada, Masaru; Kataoka, Michihiko; Shimizu, Sakayu
Tetrahedron Asymmetry, 2001 , vol. 12, # 12 p. 1713 - 1718
反应条件
1: 85 percent / NaI / butan-2-one / 15 h / Heating
2: 10 percent / broth E. coli HB101/pNTS1G; NADP+; glucose / various solvent(s) / 20 h / 30 °C / pH 6.5 / Enzymatic reaction
View Scheme
参考文献
Yasohara, Yoshihiko; Kizaki, Noriyuki; Hasegawa, Junzo; Wada, Masaru; Kataoka, Michihiko; Shimizu, Sakayu
Tetrahedron Asymmetry, 2001 , vol. 12, # 12 p. 1713 - 1718
参考文献
Larcheveque, Marc; Henrot, Serge
Tetrahedron Letters, 1987 , vol. 28, # 16 p. 1781 - 1782
