1: (4S)-4-[(1R)-1-(tert-butyldiphenylsilyloxy)-hexadec-2-enyl]-2-chloro-2-oxo-[1,3,2]-oxazaphospholidine; choline p-toluenesulfonate With triethylamine in dichloromethane; acetonitrile
T=20°C; 12 h;
2: With hydrogenchloride; water in tetrahydrofuran
3: n-hexadecanoyl chloride With tetrabutyl ammonium fluoride
more than 3 stages;
pyridine in dichloromethane
576 h; Ambient temperatureother time, other amounts of palmitoyl chloride and pyridine; also with palmitic anhydride, other alkylarsonic acid; Product distribution;
参考文献
Tsivgoulis, Gerasimos M.; Sotiropoulos, Demetrios N.; Ioannou, Panayiotis V.
Phosphorus, Sulfur and Silicon and the Related Elements, 1991 , vol. 55, # 1-4 p. 165 - 168
