(1R,2R)-反-1,2-环己二醇合成路线 （共 93 条）
反应条件
1: trans-1,2-cyclohexanediol With (5aS,10bR)-9-nitro-2-phenyl-4,5a,6,10b-tetrahydroindeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; 4-(N,N-dimethylamino)benzoic acid; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in chloroform T=20°C; 0.166667 h; 2: 2-bromo-3-phenylpropanal in chloroform T=0°C; 8 h; SolventReagent/catalyst;
参考文献
Kuwano, Satoru; Harada, Shingo; Kang, Bubwoong; Oriez, Raphael; Yamaoka, Yousuke; Takasu, Kiyosei; Yamada, Ken-Ichi
Journal of the American Chemical Society, 2013 , vol. 135, # 31 p. 11485 - 11488
反应条件
C43H60N6O8; N-ethyl-N,N-diisopropylamine in toluene T=0°C; 6 h; Inert atmosphere; enantioselective reaction;
参考文献
Hofmann, Christine; Schuler, Soeren M. M.; Wende, Raffael C.; Schreiner, Peter R.
Chemical Communications, 2014 , vol. 50, # 10 p. 1221 - 1223
反应条件
hydrogen; palladium on activated charcoal in methanol 3 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 50, # 35 p. 10521 - 10530
反应条件
water in hexane 168 h; enzyme-catalyzed hydrolysis with lipase Amano P30 (phosphate buffer, sodium chloride, pH 7.0, maintained with aq. NaOH);
参考文献
Journal of Organic Chemistry, , vol. 56, # 26 p. 7251 - 7256
反应条件
1: 97 percent / potassium hydroxide / methanol; H2O / 2 h / 20 °C 2: 51 percent / p-toluenesulfonic acid monohydrate; hydrogen / Pd/C / dioxane / 4.5 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 66, # 1 p. 405 - 431
反应条件
1: With iodosylbenzene; L-proline in N,N-dimethyl-formamide T=20°C; 2: With sodium tetrahydroborate in N,N-dimethyl-formamide T=0°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 46, # 12 p. 2053 - 2057
反应条件
1: With (1'-14C)-dodecanoic acid; dihydrogen peroxide in water; acetonitrile T=30°C; 24 h; Enzymatic reaction; 2: With water T=25°C; pH=8; 48 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Green Chemistry, , vol. 13, # 9 p. 2452 - 2458
反应条件
β-D-glucosidase T=37°C; 2 h;
参考文献
Carbohydrate Research, , vol. 87, p. 27 - 34
反应条件
lipase enzyme from Pseudomonas sp in water T=20°C; 22 h; in 0.1M phosphate buffer (pH 7);
参考文献
Journal of the Chemical Society, Chemical Communications, , # 3 p. 148 - 150
