1: 3-trifluoromethyl-aniline With sulfuric acid; sodium nitrite in water T=-5 - 0°C; 0.5 h; 2: acetaldehyde oxime With copper diacetate; sodium acetate; sodium sulfite in water T=20°C; 0.5 h; 3: With hydroxylamine; potassium carbonate in water 2 h; Heating; Further stages.;
carbon monoxide; (CH3)2NC3H6NH-substituted polystyrene; water; Rh6(CO)12 in 2-ethoxy-ethanol T=40°C; P=6080 Torr; 5 h; Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 64, # 2 p. 602 - 612
1: 3-bromo-5-(trifluoromethyl)-phenylamine With hydrogenchloride; sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: acetaldehyde oxime With copper(II) sulfate in water T=20°C; 4 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 76 ;
US 20070249607 A1
carbon monoxide; (CH3)2NC3H6NH-substituted polystyrene; water; Rh6(CO)12 in 2-ethoxy-ethanol T=40°C; P=6080 Torr; 5 h; Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 64, # 2 p. 602 - 612
