N-甲氧基-N-甲基丙酰胺合成路线 （共 14 条）
反应条件
in tetrahydrofuran T=-78 - 20°C;
参考文献
Silva, Franck; Reiter, Maud; Mills-Webb, Rebecca; Sawicki, Marcin; Klaer, Daniel; Bensel, Nicolas; Wagner, Alain; Gouverneur, Veronique
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8390 - 8394
反应条件
1: 1-bromo-4-fluorobenzene With magnesium in tetrahydrofuran T=20°C; Inert atmosphere; 2: N-methoxy-N-methylpropionamide in tetrahydrofuran T=-20 - 20°C; Inert atmosphere; 3: With water in tetrahydrofuran
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
反应条件
1: (E)-4-methoxyacetophenone tosylhydrazone With Mes2Mg; lithium chloride in tetrahydrofuran T=40°C; Shapiro reaction; 3 h; 2: N-methoxy-N-methylpropionamide in tetrahydrofuran T=40°C; 1 h; 3: With water-d2 in tetrahydrofuran
参考文献
Kerr, William J.; Morrison, Angus J.; Pazicky, Marek; Weber, Tina
Organic Letters, 2012 , vol. 14, # 9 p. 2250 - 2253
反应条件
1: 1-trifluoromethyl-4-bromobenzene With magnesium in tetrahydrofuran T=20°C; Inert atmosphere; 2: N-methoxy-N-methylpropionamide in tetrahydrofuran T=-20 - 20°C; Inert atmosphere; 3: With water in tetrahydrofuran
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran T=20°C; Inert atmosphere; 2: N-methoxy-N-methylpropionamide in tetrahydrofuran T=-20 - 20°C; Inert atmosphere; 3: With water in tetrahydrofuran
参考文献
Angewandte Chemie, International Edition, , vol. 48, p. 4543 - 4545
Angewandte Chemie, , vol. 121, p. 4613 - 4615
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 1 h;
参考文献
Kerr, William J.; Morrison, Angus J.; Pazicky, Marek; Weber, Tina
Organic Letters, 2012 , vol. 14, # 9 p. 2250 - 2253
反应条件
triethylamine in dichloromethane
T=0 - 10°C; Inert atmosphere;
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
参考文献
Persson, Tobias; Nielsen, John
Organic Letters, 2006 , vol. 8, # 15 p. 3219 - 3222
参考文献
Guanti, Giuseppe; Banfi, Luca; Narisano, Enrica
Tetrahedron Letters, 1986 , vol. 27, # 30 p. 3547 - 3550
反应条件
1: 4-bromo-N,N-dimethyl-aniline With magnesium in tetrahydrofuran
T=20°C; Inert atmosphere;
2: N-methoxy-N-methylpropionamide in tetrahydrofuran
T=-20 - 20°C; Inert atmosphere;
3: With water in tetrahydrofuran
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
