2-氧代环戊烷羧酸甲酯合成路线 （共 119 条）
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C 1.2: dimethylformamide / 18 h 2.1: 2.87 g / HBr / 12 h / Heating View Scheme
参考文献
Wang, Shaozhao; Chen, Gang; Kayser, Margaret M.; Iwaki, Hiroaki; Lau, Peter C.K.; Hasegawa, Yoshie
Canadian Journal of Chemistry, 2002 , vol. 80, # 6 p. 613 - 621
反应条件
lithium chloride in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=160°C;
参考文献
Asaoka,M. et al.
Chemistry Letters, 1975 , p. 1149 - 1152
反应条件
hydrogen; nickel in methanol T=50°C; P=750.06 Torr;
参考文献
Yamano, Toru; Taya, Naohiro; Kawada, Mitsuru; Huang, Taisheng; Imamoto, Tsuneo
Tetrahedron Letters, 1999 , vol. 40, # 13 p. 2577 - 2580
反应条件
1: 75 percent / p-TsOH / 0.5 h / 20 °C 2: 87 percent / LiAlH4 / tetrahydrofuran / 15 h / 0 °C View Scheme
参考文献
Kato; Ikeda; Sugita; Nitta; Enari; Kashima; Konno; Niimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2152 - 2158
反应条件
1: ammonium formate / methanol / 24 h / |Reflux 2: acetic anhydride / 4 h / 20 °C / |Cooling with ice 3: ammonium formate; formamide / 16 h / 20 - 150 °C 4: trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
Gangjee, Aleem; Zhao, Ying; Raghavan, Sudhir; Rohena, Cristina C.; Mooberry, Susan L.; Hamel, Ernest
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6829 - 6844
反应条件
1: acetamide With acetyl chloride in acetic acid 0.25 h; Cooling with ice; 2: methyl 2-oxo-cyclopentane-1-carboxylate With phosphorus trichoride in acetic acid T=20°C; Cooling with ice; Further stages;
参考文献
Ziora, Zyta; Kafarski, PaweL
Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 4 p. 1047 - 1053
反应条件
C17H23BN2O; sodium methylate T=50°C; retro-Dieckmann condensation; P=760.051 Torr; 72 h; Inert atmosphere;
参考文献
Oishi, Shunsuke; Saito, Susumu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 22 p. 5395 - 5399
反应条件
toluene-4-sulfonic acid 24 h; Heating;
参考文献
Fraga; Barreiro
Synthetic Communications, 1995 , vol. 25, # 8 p. 1133 - 1144
反应条件
1: acetamide With acetyl chloride in acetic acid 0.25 h; Cooling with ice; 2: methyl 2-oxo-cyclopentane-1-carboxylate With phosphorus trichoride in acetic acid T=20°C; Cooling with ice; Further stages;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 184, # 4 p. 1047 - 1053
反应条件
1: 93 percent / TsOH / CH2Cl2 2: 97 percent / lithium aluminum hydride / diethyl ether / 0 °C 3: 80 percent / concd. phosphoric acid, hydroquinone / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Polish Journal of Chemistry, , vol. 68, # 2 p. 321 - 322
