1-甲基-3-苯基-1H-吡唑-5-羧酸乙酯合成路线 （共 7 条）
反应条件
1: acetophenone; oxalic acid diethyl ester With sodium hydride in ethanol; mineral oil T=20°C; 2: methylhydrazine With hydrogenchloride in ethanol; water
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18428 A1, 2004 ;
Location in patent: Page 92 ;
反应条件
in acetic acid; ethyl acetate
参考文献
Eisai Co., Ltd.
Patent: EP1216980 A1, 2002 ;
EP 1216980 A1
反应条件
1: 96.4 percent / Na; EtOH / toluene 2: 40.7 percent / ethanol / 5 h / Heating View Scheme
参考文献
Schmidt, Andreas; Habeck, Tobias; Kindermann, Markus Karl; Nieger, Martin
Journal of Organic Chemistry, 2003 , vol. 68, # 15 p. 5977 - 5982
反应条件
in ethanol 5 h; Heating;
参考文献
Schmidt, Andreas; Habeck, Tobias; Kindermann, Markus Karl; Nieger, Martin
Journal of Organic Chemistry, 2003 , vol. 68, # 15 p. 5977 - 5982
反应条件
2 h; Heating; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Martins, Marcos A. P.; Freitag, Rogerio A.; Da Rosa, Adriano; Flores, Alex F. C.; Zanatta, Nilo; Bonacorso, Helio G.
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 217 - 220
反应条件
sodium hydroxide in ethanol
参考文献
EP1216980 A1, ;
EP 1216980 A1
反应条件
in tetrahydrofuran; methanol; water
