2,6-二氨基-4-嘧啶醇合成路线 （共 16 条）
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogenchloride in water T=90°C; 0.5 h; 2: With sodium acetate in water T=20°C; 3: 2,4-diamino-6(1H)-pyrimidone in water T=80°C; 2 h;
参考文献
Brueckl, Tobias; Thoma, Ines; Wagner, Andreas J.; Knochel, Paul; Carell, Thomas
European Journal of Organic Chemistry, 2010 , # 34 p. 6517 - 6519
参考文献
Han, Bo; Rajwanshi, Vivek; Nandy, Jyoti; Krishnamurthy, Ramanarayanan; Eschenmoser, Albert
Synlett, 2005 , # 5 art. no. S10704ST, p. 744 - 750
反应条件
water; sodium acetate in 1,4-dioxane regiospecific reaction;
参考文献
Gao, Ling-Jie; Schwed, J. Stephan; Weizel, Lilia; De Jonghe, Steven; Stark, Holger; Herdewijn, Piet
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 132 - 137
反应条件
sodium acetate 5 h; Heating;
参考文献
Gangjee; Vidwans; Elzein; McGuire; Queener; Kisliuk
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1993 - 2003
反应条件
1: formic acid methyl ester; chloroacetonitrile With sodium methylate in tetrahydrofuran T=0 - 20°C; 5 h; 2: 2,4-diamino-6(1H)-pyrimidone With sodium acetate in tetrahydrofuran; water 12 h;
参考文献
Klepper, Florian; Polborn, Kurt; Carell, Thomas
Helvetica Chimica Acta, 2005 , vol. 88, # 10 p. 2610 - 2616
反应条件
sodium acetate in tetrahydrofuran 0 deg C, room temperature - 12 h; Title compound not separated from byproducts;
参考文献
Migawa, Michael T.; Hinkley, Jack M.; Hoops, Geoffrey C.; Townsend, Leroy B.
Synthetic Communications, 1996 , vol. 26, # 17 p. 3317 - 3322
参考文献
Ulbricht; Price
Journal of Organic Chemistry, 1956 , vol. 21, p. 567,571
Full Text Show Details
Bendich; Clements
Biochimica et Biophysica Acta, 1953 , vol. 12, p. 462,474
反应条件
4-methyl-aniline-hydrochloride T=130 - 140°C; 0.833333 h;
参考文献
Aoyagi; Yanada; Bessho; Yoneda; Armarego
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1537 - 1539
反应条件
hydrogen bromide in ethanol; water; isopropyl alcohol T=78°C; Heating / reflux;
参考文献
AGOURON PHARMACEUTICALS, MINC.
Patent: US2005/85492 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
hydrogen bromide; acetic acid in ethanol 72 h; Heating;
参考文献
Tomsho, John W.; McGuire, John J.; Coward, James K.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 18 p. 3388 - 3398
