(2S)-2-呋喃基(羟基)乙腈合成路线 （共 12 条）
反应条件
(R)-oxynitrilase (almond meal) in di-isopropyl ether T=4°C; 48 h;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 11 p. 1835 - 1838
反应条件
1: trimethylsilyl cyanide With methanol; C60H48LiN2O4P2Ru(1+)*Cl(1-) Inert atmosphereCooling; 2: furfural in tert-butyl methyl ether T=-70°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 5 p. 1254 - 1257
反应条件
ytterbium trichloride; 2,6-bis(iPr-2-oxazolin-2-yl)pyridine in acetonitrile 2 h; Ambient temperature; Yield givenYields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 40, # 9 p. 1763 - 1766
反应条件
cyclo-lt;(R)-phenylalanyl-(R)-histidylgt;; (S)-PhOPhCH(OH)CN in toluene T=-25°C; 7 h; effect of additives; further aldehydes; enantiselective autoinduction in cyanohydrin formation by cyclo<(R)-His-(R)-Phe>; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 63, # 14 p. 4604 - 4610
反应条件
Prunus mume (R)-hydroxynitrile lyase; citrate buffer in di-isopropyl ether pH=4.0; 78 h;
参考文献
Tetrahedron, , vol. 61, # 46 p. 10908 - 10916
反应条件
1: potassium cyanide With citric acid in di-isopropyl ether; water T=20°C; 0.5 h; 2: furfural in di-isopropyl ether T=20°C; 0.5 h; aq. bufferEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron, , vol. 65, # 9 p. 1919 - 1927
反应条件
1: 2-hydroxy-2-methyl-propionitrile With (-)-(R,R)-TADDOL; zirconium tetra-t-butoxide in dichloromethane T=20°C; Complexation; 1 h; 2: furfural in dichloromethane T=-40°C; Addition; Meerwein-Ponndorf-Verley cyanation; 18 h; Title compound not separated from byproducts;
参考文献
Synlett, , # 8 p. 1133 - 1134
反应条件
hydrogenchloride in water; acetic acid T=40°C; 3 h; Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 1 p. 111 - 120
反应条件
R-oxynitrilase (E.C. 4.1.2.10) from almond meal in water pH=5.5;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1645 - 1652
反应条件
1: tetrabutylammonium bromide, HCl conc. / diethyl ether; H2O / a) 0 deg C, 1.5 h, b) RT, 30 min 2: 1.) isopropenyl acetate, 2.) imidazole / 1.) i-Pr2O, lipase, 40 deg C, 47 h, 2.) i-Pr2O, DMF, RT, overnight 3: HCl conc. / acetic acid; H2O / 3 h / 40 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 1 p. 111 - 120
