3-溴-(1-苯磺酰)吲哚合成路线 （共 25 条）
反应条件
bromine in dichloromethane 2 h;
参考文献
Davis, Deborah A.; Gribble, Gordon W.
Heterocycles, 1992 , vol. 34, # 8 p. 1613 - 1621
反应条件
1: 99 percent / NaOH; (n-Bu)4NHSO4 / CH2Cl2 2: 95 percent / Br2 / CCl4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 15 p. 3412 - 3415
反应条件
1: FeCl3; NaBr / acetonitrile / 7 h 2: NaOH; tetrabutylammonium hydrogensulfate / benzene / 1 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 14 p. 3242 - 3247
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate 1.) benzene, 5 min, 2.) 2 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 51, # 12 p. 2343 - 2351
反应条件
1: 71 percent / m-chloroperbenzoic acid (m-CPBA) / CH2Cl2 / 14 h / Ambient temperature 2: 1.) PhMgBr, anthracene, 2.) MeI / 1.) diglyme, Et2O, reflux, 10 h, 2.) diglyme, Et2O, overnight View Scheme
参考文献
Heterocycles, , vol. 34, # 11 p. 2095 - 2108
反应条件
anthracene; phenyl-magnesium bromide; methyl iodide 1.) diglyme, Et2O, reflux, 10 h, 2.) diglyme, Et2O, overnight; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 34, # 11 p. 2095 - 2108
反应条件
tert.-butyl lithium; copper (I) cyanide 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
反应条件
1: 67 percent / LDA; CNBr / tetrahydrofuran 2: 83 percent / P(o-tolyl)3; K2CO3 / Pd(OAc)2 / acetone; H2O / 5 h / 70 °C 3: 89 percent / Mg / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 45 p. 8717 - 8721
反应条件
1: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1 a) -95 deg C, 6 min b) -90 deg C, 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h 2: lithium diisopropylamine / 1.) THF, hexane, -70 deg C, 1.5 h, 2.) -65 deg C to RT, 15 h View Scheme
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
反应条件
tert.-butyl lithium; copper (I) cyanide 1.) pentane, THF-Et2O 3:1, a) -95 deg C, 6 min, b) 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wenkert, Ernest; Angell, E. Charles; Ferreira, Vitor F.; Michelotti, Enrique L.; Piettre, Serge R.; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2343 - 2351
