1: 6-bromo-5-methoxy-2,3-dihydro-benzofuran With n-butyllithium in tetrahydrofuran
T=-25°C; Metallation;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-25°C; Formylation;
参考文献
SmithKline Beecham Corporation
Patent: US6353116 B1, 2002 ;
Location in patent: Page column 21 ;
US 6353116 B1
titanium tetrachloride in dichloromethane
1.5 h; Ambient temperature;
参考文献
Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918
Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918
Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918
Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918