3-溴-4-甲氧基苯甲酸合成路线 （共 47 条）
反应条件
lithium diisopropyl amide 1.) THF, hexane, -70 deg C, 10 min, 2.) THF, hexane, -70 deg C -> room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wang, Anlai; Maguire, John A.; Biehl, Ed
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2451 - 2455
反应条件
(4-methoxy-phenyl)-acetonitrile; lithium diisopropyl amide 1.) THF, hexane, -70 deg C, 10 min; other reagents: LDA/phenylacetonitrile, LDA/2-methoxyphenylacetonitrile, LDA/1-naphthylacetonitrile, 2.) THF, hexane, -70 deg C -> room temperature; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wang, Anlai; Maguire, John A.; Biehl, Ed
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2451 - 2455
反应条件
lithium diisopropyl amide 1.) THF, hexane, -70 deg C, 10 min, 2.) THF, hexane, -70 deg C -> room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wang, Anlai; Maguire, John A.; Biehl, Ed
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2451 - 2455
反应条件
lithium diisopropyl amide 1.) THF, hexane, -70 deg C, 10 min, 2.) THF, hexane, -70 deg C -> room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wang, Anlai; Maguire, John A.; Biehl, Ed
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2451 - 2455
反应条件
potassium carbonate durch Schmelzen;
参考文献
Barth
Justus Liebigs Annalen der Chemie, 1871 , vol. 159, p. 232
参考文献
Balbiano
Gazzetta Chimica Italiana, 1884 , vol. 14, p. 235
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; 3 h; Microwave irradiation;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2009/78983 A1, 2009 ;
Location in patent: Page/Page column 86 ;
WO 2009/078983 A1
反应条件
hydrogen bromide; acetic acid
参考文献
Tomita; Fujitani
Yakugaku Zasshi, 1956 , vol. 76, p. 1126
Chem.Abstr., 1957 , p. 3506
反应条件
[bis(acetoxy)iodo]benzene; lithium bromide in 2,2,2-trifluoroethanol T=20°C; Hunsdiecker type reaction; 4 h;
参考文献
Hamamoto, Hiromi; Hattori, Sho; Takemaru, Kaori; Miki, Yasuyoshi
Synlett, 2011 , # 11 p. 1563 - 1566
参考文献
SmithKline Beecham, p.l.c.
Patent: US6277861 B1, 2001 ;
