2-氯-3-氰基-4-甲氧基吡啶合成路线 （共 7 条）
反应条件
trichlorophosphate in water 2 h;
参考文献
Sankyo Company, Limited
Patent: EP1764367 A1, 2007 ;
Location in patent: Page/Page column 142 ;
反应条件
hydrogenchloride in methanol
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: T=100°C; 1 h; 2: With hydrogenchloride in methanol T=0°C; 15.5 h; Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7374 - 7388
反应条件
hydrogen; triethylamine; palladium dichloride in N,N-dimethyl-formamide P=2574.3 Torr; 2 h; Ambient temperature;
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: triethylamine, H2 / PdCl2 / dimethylformamide / 2 h / 2574.3 Torr / Ambient temperature 2: 75 percent / conc. aq. HCl / 6.5 h / Heating View Scheme
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; hexane
4 h; Heating;
参考文献
Ferlin, Maria Grazia; Di Marco, Valerio B.; Dean, Annalisa
Tetrahedron, 2006 , vol. 62, # 26 p. 6222 - 6227
反应条件
1: 99 percent / (Ph3P)4Pd / dioxane; hexane / 4 h / Heating
2: 45 percent / HBr / H2O / Heating
View Scheme
参考文献
Ferlin, Maria Grazia; Di Marco, Valerio B.; Dean, Annalisa
Tetrahedron, 2006 , vol. 62, # 26 p. 6222 - 6227
