2,4-二氯-5-甲氧基苯胺合成路线 （共 13 条）
反应条件
silver carbonate; copper dichloride; palladium dichloride in tetrahydrofuran T=110°C; 24 h;
参考文献
Peng, Xuefeng; Shao, Xiang-Feng; Liu, Zhong-Quan
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3079 - 3081
参考文献
Journal of the American Chemical Society, , vol. 41, p. 460
反应条件
1: KOH-solution 2: hydrochloric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 41, p. 460
反应条件
1: glacial acetic acid; chlorine / 15 - 20 °C 2: KOH-solution 3: hydrochloric acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 41, p. 460
反应条件
1.1: 69 percent / pyridine hydrochloride / 2-ethoxy-ethanol / 3 h / 120 °C 2.1: NaH / dimethylformamide / 0.08 h / 100 °C 2.2: 55 percent / dimethylformamide / 2 h / 120 °C View Scheme
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
反应条件
boron tribromide in dichloromethane T=20°C;
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
反应条件
in DMF (N,N-dimethyl-formamide) T=10 - 20°C; 2 h; Product distribution / selectivity;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
diisopropyl-carbodiimide in tetrahydrofuran 0.5 h; Heating;
参考文献
WYETH
Patent: WO2006/47262 A1, 2006 ;
Location in patent: Page/Page column 13-14 ;
反应条件
in DMF (N,N-dimethyl-formamide) T=10 - 20°C; 2 h; Product distribution / selectivity;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
1: pyridine / dichloromethane / 0.33 h / 20 °C 2: hydrogen; palladium 10 on activated carbon / N,N-dimethyl-formamide / 12 h / 20 °C / 750.08 Torr 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 15.5 h / 20 °C View Scheme
参考文献
Matsumoto, Yotaro; Noguchi-Yachide, Tomomi; Nakamura, Masaharu; Mita, Yusuke; Numadate, Akiyoshi; Hashimoto, Yuichi
Heterocycles, 2012 , vol. 86, # 2 p. 1449 - 1463
