3,3-二甲氧基环丁烷-1-羧酸甲酯合成路线 （共 13 条）
反应条件
1: With sodium hydroxide; water in methanol T=20°C; 2: With citric acid in methanol; diethyl ether; water Product distribution / selectivity;
参考文献
Pfizer Inc
Patent: US2008/280879 A1, 2008 ;
Location in patent: Page/Page column 22; 23 ;
US 20080280879 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 12 h;
参考文献
Pfizer Inc
Patent: US2005/171181 A1, 2005 ;
Location in patent: Page/Page column 18 ;
US 20050171181 A1
反应条件
toluene-4-sulfonic acid in methanol
2 h; Heating / reflux;
参考文献
Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios
Patent: US2008/21032 A1, 2008 ;
Location in patent: Page/Page column 83 ;
US 20080021032 A1
反应条件
toluene-4-sulfonic acid in toluene
10 h; Heating / reflux;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1935883 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
toluene-4-sulfonic acid in methanol; dichloromethane
T=20°C; 2 h;
参考文献
MERCK and CO. INC.
Patent: WO2004/82682 A1, 2004 ;
Location in patent: Page 72-73 ;
WO 2004/082682 A1
反应条件
toluene-4-sulfonic acid
8 h; Heating;
参考文献
Stevens; De Kimpe
Journal of Organic Chemistry, 1996 , vol. 61, # 6 p. 2174 - 2178
反应条件
sulfonic acid type-ion exchange resin in dichloromethane
T=20°C; 18 h; not specified;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/119720 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/119720 A1
反应条件
sodium cyanide
T=30°C; Further byproducts given;
参考文献
Hoz, S.; Aurbach, D.
Tetrahedron, 1985 , vol. 41, # 7 p. 1307 - 1314
反应条件
in methanol
T=30°C; 336 h; Further byproducts given;
参考文献
Hoz, S.; Aurbach, D.
Tetrahedron, 1985 , vol. 41, # 7 p. 1307 - 1314
反应条件
in methanol
T=30°C; 336 h; Further byproducts given;
参考文献
Hoz, S.; Aurbach, D.
Tetrahedron, 1985 , vol. 41, # 7 p. 1307 - 1314
