4-{[(苄氧基)羰基](甲基)氨基}丁酸合成路线 （共 6 条）
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 24 h;
参考文献
Kinney, William A.; Lawson, Edward C.; Ghosh, Shyamali; Luci, Diane K.; McComsey, David F.
Patent: US2008/318973 A1, 2008 ;
Location in patent: Page/Page column 53 ;
反应条件
1: With potassium hydroxide in water
2 h;
2: With hydrogenchloride in water
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/103035 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
sodium hydroxide in ethanol; water
T=0 - 20°C;
参考文献
Lee, Hyung Kook; Lee, Yun Suk; Roh, Eun Joo; Rhim, Hyewhon; Lee, Jae Yeol; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4424 - 4427
反应条件
potassium hydroxide in water; toluene
2 h;
参考文献
Ashcroft, Christopher P.; Pettman, Alan; Watkinson, Simon; Hellier, Paul
Organic Process Research and Development, 2011 , vol. 15, # 1 p. 98 - 103
反应条件
1: water; Ba(OH)2 / 5 h / |Reflux
2: potassium hydroxide / water / 2.17 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY; MADATHIL, Manikandadas, Mathilakathu; KHDOUR, Omar; HECHT, Sidney
Patent: WO2014/59158 A1, 2014 ;
反应条件
1: 4-{[(benzyloxy)carbonyl](methyl)amino}butanoic acid With 1,1'-carbonyldiimidazole in dichloromethane
1 h;
2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane
16 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/103035 A1, 2005 ;
Location in patent: Page/Page column 11-12 ;
