4-甲基-4-三氟甲基-联苯合成路线 （共 42 条）
反应条件
lithium aluminium tetrahydride; titanium tetrachloride in ethylene glycol dimethyl ether 0.333333 h; Reflux;
参考文献
Akiyama, Takahiko; Atobe, Kohei; Shibata, Michiko; Mori, Keiji
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 81 - 83
反应条件
potassium carbonate in water
T=80°C; Suzuki coupling; 3 h;
参考文献
Ohtaka, Atsushi; Kono, Yuki; Teratani, Takuto; Fujii, Syuji; Matsuzawa, Soichiro; Nakamura, Yoshinobu; Nomura, Ryoki
Catalysis Letters, 2011 , vol. 141, # 8 p. 1097 - 1103
反应条件
potassium carbonate in water
T=80°C; Suzuki coupling; 3 h;
参考文献
Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich
Tetrahedron, 2014 , vol. 70, # 17 p. 2829 - 2837
反应条件
potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl in water
T=50°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Uozumi, Yasuhiro; Nakai, Yasushi
Organic Letters, 2002 , vol. 4, # 17 p. 2997 - 3000
反应条件
tri-tert-butyl phosphine; boronic acid; caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
T=80 - 90°C; 5 h;
参考文献
Littke, Adam F.; Fu, Gregory C.
Angewandte Chemie - International Edition, 1999 , vol. 37, # 24 p. 3387 - 3388
反应条件
PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada cross-coupling reaction; 22 h;
参考文献
Ackermann, Lutz; Althammer, Andreas
Organic Letters, 2006 , vol. 8, # 16 p. 3457 - 3460
反应条件
palladium diacetate; potassium carbonate in ethanol; N,N-dimethyl acetamide
T=80°C; Suzuki coupling; 0.666667 h;
参考文献
Yang, Weibo; Liu, Chun; Qiu, Jieshan
Chemical Communications, 2010 , vol. 46, # 15 p. 2659 - 2661
反应条件
1: para-bromotoluene With lithium
2: With zinc(II) chloride
3: 1-chloro-4-(trifluoromethyl)benzene With nickel phosphine amido pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; Negishi cross-coupling; 12 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
1: triallyl(4-methylphenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 1-chloro-4-(trifluoromethyl)benzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 3 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
chloro(1,3-bis(pyridin-2-ylmethyl)imidazolylidene)nickel(II) hexafluorophosphate in tetrahydrofuran
T=20°C; Kumada-Corriu coupling reaction; 12 h; Inert atmosphere;
参考文献
Chen, Chao; Qiu, Huayu; Chen, Wanzhi
Journal of Organometallic Chemistry, 2012 , vol. 696, # 26 p. 4166 - 4172
