(2R,3S)-rel-3-(4-甲氧基苯基)-2-环氧乙烷羧酸甲酯合成路线 (共 26 条)
反应条件
1: aq. FeCl3 / chlorobenzene / 0.75 h / 115 °C 2: methanesulfonic acid / chlorobenzene / 8 h / Heating View Scheme
参考文献
Yamada, Shin-Ichi; Yoshioka, Ryuzo; Shibatani, Takeji
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 1922 - 1927
反应条件
in toluene 0.366667 h; Irradiationmicrowave, 390 watts; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Vega, Juan A.; Cueto, Senida; Ramos, Andres; Vaquero, Juan J.; Garcia-Navio, Jose L.; Alvarez-Builla, Julio; Ezquerra, Jesus
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6413 - 6416
反应条件
in toluene 0.166667 h; Irradiationmicrowave, 350 watts; Yields of byproduct given;
参考文献
Vega, Juan A.; Cueto, Senida; Ramos, Andres; Vaquero, Juan J.; Garcia-Navio, Jose L.; Alvarez-Builla, Julio; Ezquerra, Jesus
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6413 - 6416
反应条件
T=165°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Hashiyama, Tomiki; Inoue, Hirozumi; Konda, Mikihiko; Takeda, Mikio
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1256 - 1259
反应条件
sodium hydrogencarbonate in ethanol Ambient temperaturefurther catalysts; Title compound not separated from byproducts;
参考文献
Hashiyama, Tomiki; Inoue, Hirozumi; Konda, Mikihiko; Takeda, Mikio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1725 - 1732
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=22°C; 6.5 h;
参考文献
Hashiyama, Tomiki; Inoue, Hirozumi; Takeda, Mikio; Aoe, Keiichi; Kotera, Keishi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 421 - 428
反应条件
in tert-butyl alcohol T=50°C; 19 h; Yield given. Yields of byproduct given;
参考文献
Hashiyama, Tomiki; Inoue, Hirozumi; Takeda, Mikio; Aoe, Keiichi; Kotera, Keishi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 421 - 428
反应条件
water; lipase from Candida cylindracea in 1,1-dimethylpropan-1-ol T=22°C; 24 h; other primary alcohols; other solvents, other reaction conditions; enantioselectivity; effect of water; Product distribution;
参考文献
Kanerva, Liisa T.; Sundholm, Oskari
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 13 p. 1385 - 1390
反应条件
in cyclohexane; water 1.5 h; Ambient temperatureenzymatic hydrolysis by lipase from Candida cylindracea (CCL), pH 7.4, other enzymes; enzymatic transesterification;
参考文献
Gentile; Giordano; Fuganti; Ghirotto; Servi
Journal of Organic Chemistry, 1992 , vol. 57, # 24 p. 6635 - 6635
反应条件
lipase type VII in cyclohexane T=33°C; 9.5 h; Enzymatic reaction;
参考文献
Zambon Group S.p.A.
Patent: US6346632 B1, 2002 ;
Location in patent: Page column 7 ;