4-甲基-3-硝基苯甲酸合成路线 （共 85 条）
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 2: triethylamine / dichloromethane / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C View Scheme
参考文献
Brown, Dearg S.; Cumming, John G.; Bethel, Paul; Finlayson, Jonathan; Gerhardt, Stefan; Nash, Ian; Pauptit, Richard A.; Pike, Kurt G.; Reid, Alan; Snelson, Wendy; Swallow, Steve; Thompson, Caroline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3879 - 3883
反应条件
1.1: hydrogenchloride / 20 h / 90 °C / Inert atmosphere 2.1: sodium ethanolate / ethanol / 16 h / 20 °C 2.2: pH 7 3.1: zinc; acetic acid / water / 1 h / 85 °C View Scheme
参考文献
WO2011/71716 A1, ;
WO 2011/071716 A1
反应条件
1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C 2: hydrogen; palladium on activated charcoal / methanol / 20 °C View Scheme
参考文献
EP2551262 A1, ;
EP 2551262 A1
反应条件
1.1: hydrogenchloride / 3 h / Reflux 2.1: isobutyramide / 3 h / 100 °C 3.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 20 °C 4.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 60 °C 4.2: pH 3 View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid 2: sulfuric acid / |Reflux; |Molecular sieve 3: tin(ll) chloride / ethanol / 0.5 h / |Reflux 4: acetic acid; sodium nitrite / water 5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
反应条件
hydrogen; palladium in methanol 5 h;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 16, # 3 p. 275 - 277
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 16, # 3 p. 366 - 368
参考文献
Chemische Berichte, , vol. 26, p. 1733
反应条件
hydrogenchloride T=90°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
Location in patent: Page/Page column 39-40 ;
WO 2011/071716 A1
反应条件
1: thionyl chloride / 3 h / Heating 2: 95 percent / 8 h / Heating View Scheme
参考文献
Desrousseaux; Bennetau; Morand; Mingotaud; Letard; Montant; Freysz
New Journal of Chemistry, 2000 , vol. 24, # 12 p. 977 - 985
反应条件
phosphorus pentachloride Behandlung des erhaltenen Chlorids mit konz. Ammoniak;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1847535 A1, 2007 ;
Location in patent: Page/Page column 32 ;
EP 1847535 A1
