反-4-[4-(3-戊烯基)环己基]苄腈合成路线 （共 7 条）
反应条件
in tert-butyl methyl ether; water; ethyl acetate; Petroleum ether
参考文献
Hoffmann-La Roche Inc.
Patent: US4709030 A1, 1987 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-20°C; 1.16667 h; Yield given;
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
反应条件
1: 29 percent / 2N HCl / tetrahydrofuran / 0.5 h / Heating
2: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
3: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
4: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
5: 0.8 M n-BuLi / tetrahydrofuran; hexane / 1.17 h / -20 °C
View Scheme
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
反应条件
1: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
2: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
3: 0.8 M n-BuLi / tetrahydrofuran; hexane / 1.17 h / -20 °C
View Scheme
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
反应条件
1: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
2: 0.8 M n-BuLi / tetrahydrofuran; hexane / 1.17 h / -20 °C
View Scheme
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
反应条件
1: 94 percent / t-BuOK / various solvent(s); tetrahydrofuran / 2.75 h / -10 - 25 °C
2: 29 percent / 2N HCl / tetrahydrofuran / 0.5 h / Heating
3: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
4: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
5: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
6: 0.8 M n-BuLi / tetrahydrofuran; hexane / 1.17 h / -20 °C
View Scheme
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
反应条件
1: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
2: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
3: 1.) t-BuOK; 2.) 2N HCl / 1.) t-butyl methyl ether, -10 deg C - RT, 165 min; 2.) THF, reflux, 30 min
4: 0.8 M n-BuLi / tetrahydrofuran; hexane / 1.17 h / -20 °C
View Scheme
参考文献
Petrzilka, Martin
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 109 - 124
