1,1-二氰基-2-甲氧基-4-二甲基氨基-1,3-丁二烯合成路线 （共 15 条）
反应条件
in methanol 1.5 h; Heating;
参考文献
Ferlin, Maria Grazia; Di Marco, Valerio B.; Dean, Annalisa
Tetrahedron, 2006 , vol. 62, # 26 p. 6222 - 6227
反应条件
in methanol 0.5 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 60, p. 410 - 420
参考文献
WO2006/81072 A1, ;
Page/Page column 47-48 ;
WO 2006/081072 A1
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
hydrogenchloride in methanol
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
ammonium hydroxide 1 h; Heating;
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: 83 percent / HCl / methanol 2: triethylamine, H2 / PdCl2 / dimethylformamide / 2 h / 2574.3 Torr / Ambient temperature View Scheme
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: 83 percent / HCl / methanol 2: triethylamine, H2 / PdCl2 / dimethylformamide / 2 h / 2574.3 Torr / Ambient temperature 3: 75 percent / conc. aq. HCl / 6.5 h / Heating View Scheme
参考文献
Mittelbach; Kastner; Junek
Archiv der Pharmazie, 1985 , vol. 318, # 6 p. 481 - 486
反应条件
1: 87 percent / methanol / 15 h / Heating 2: 70 percent / CH3I / 6 h / 130 °C View Scheme
参考文献
Mittelbach, Martin; Kastner, Gabriele; Junek, Hans
Monatshefte fuer Chemie, 1984 , vol. 115, p. 1467 - 1470
反应条件
1.1: hydrogen bromide; acetic acid / 48 h / 20 °C 2.1: thiourea / methanol / 3 h / Reflux 2.2: 0.25 h / Reflux 3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C View Scheme
参考文献
Miszke, Agnieszka; Foks, Henryk; Brozewicz, Kamil; Kedzia, Anna; Kwapisz, Ewa; Zwolska, Zofia
Heterocycles, 2008 , vol. 75, # 11 p. 2723 - 2734
