(3-(2-氟苯基)异噁唑-5-基)甲醇合成路线 （共 5 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 4 h;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/118323 A1, 2007 ;
Location in patent: Page/Page column 26-27 ;
WO 2007/118323 A1
反应条件
1: o-fluorobenzaldehyde oxime With pyridine; N-chloro-succinimide in tetrahydrofuran
T=60°C; 0.75 h;
2: propargyl alcohol With triethylamine in tetrahydrofuran
16 h;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/118323 A1, 2007 ;
Location in patent: Page/Page column 26 ;
WO 2007/118323 A1
反应条件
1: 2-fluorobenzaldehyde oxime With pyridine; N-chloro-succinimide in tetrahydrofuran
T=60°C; 0.5 h;
2: propargyl alcohol With triethylamine in tetrahydrofuran
T=50°C; 2 h;
参考文献
Jung, Hee Kyung; Doddareddy, Munikumar Reddy; Cha, Joo Hwan; Rhim, Hyewhon; Cho, Yong Seo; Koh, Hun Yeong; Jung, Bong Young; Pae, Ae Nim
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 3965 - 3970
反应条件
1.1: NH2OH*HCl; Na2CO3 / ethanol; H2O / 1 h / 60 °C
2.1: N-chlorosuccinimide; pyridine / tetrahydrofuran / 0.5 h / 60 °C
2.2: triethylamine / tetrahydrofuran / 2 h / 50 °C
View Scheme
参考文献
Jung, Hee Kyung; Doddareddy, Munikumar Reddy; Cha, Joo Hwan; Rhim, Hyewhon; Cho, Yong Seo; Koh, Hun Yeong; Jung, Bong Young; Pae, Ae Nim
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 3965 - 3970
反应条件
1: With potassium permanganate in acetone
T=-5 - 0°C; 6 h;
2: With hydrogenchloride in diethyl ether; water
0.5 h; Product distribution / selectivity;
参考文献
NEUROMED PHARMACEUTICALS LTD.
Patent: WO2007/118323 A1, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/118323 A1
