3,4,5-三甲氧基苯乙酸合成路线 （共 59 条）
反应条件
sodium hypochlorite; phosphate buffer; hypochlorous acid in water T=25°C; Chlorination; 24 h; Title compound not separated from byproducts;
参考文献
Langvik, Vivi-Ann; Hormi, Osmo
Chemosphere, 1994 , vol. 28, # 6 p. 1111 - 1118
反应条件
1: 71 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating View Scheme
参考文献
Spaeth; Boehm
Chemische Berichte, 1922 , vol. 55, p. 2989
反应条件
hydrogenchloride T=200 - 250°C;
参考文献
CIBA
Patent: DE687196 , 1938 ;
DRP/DRBP Org.Chem.
反应条件
sodium azide; TEA; diethylphosphinoethane; [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane; dimethyl sulfoxide T=0°C; 50 h;
参考文献
Tetrahedron Letters, , vol. 49, # 5 p. 914 - 918
参考文献
Massarani
Farmaco, Edizione Scientifica, 1957 , vol. 12, p. 380,385
反应条件
1: 74 percent 2: 80 percent / hydrazine monohydrate / aq. ethanol / Heating View Scheme
参考文献
Ares; Messier; Kornecki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1197 - 1201
反应条件
1: i-Pr2NEt; HBTU / dimethylformamide / 18 h / 20 °C 2: NaOMe / ethanol / Heating 3: NaOMe / dimethylformamide / 2.08 h / 0 - 20 °C View Scheme
参考文献
Dymock, Brian; Barril, Xavier; Beswick, Mandy; Collier, Adam; Davies, Nicholas; Drysdale, Martin; Fink, Alexandra; Fromont, Christophe; Hubbard, Roderick E.; Massey, Andrew; Surgenor, Allan; Wright, Lisa
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 325 - 328
反应条件
potassium permanganate
参考文献
de Laire; Tiemann
Chemische Berichte, 1893 , vol. 26, p. 2019
反应条件
1: 60 percent / triethylamine / acetic anhydride / 3 h / Heating 2: 72 percent / copper; quinoline / 2 h / 200 °C View Scheme
参考文献
Liu, Ying-Qian; Li, Xiao-Jing; Zhao, Chun-Yan; Lu, Yan; Li, Wen-Qun; Liu, Zhen-Ling; Feng, Gang; Yang, Liu
Medicinal Chemistry Research, 2013 , vol. 22, # 5 p. 2196 - 2206
反应条件
1: acetic anhydride; triethylamine / 6 h / 110 °C 2: quinoline; copper / 3 h / 200 °C / Inert atmosphere View Scheme
参考文献
Xiao, Chun-Fen; Zou, Yong; Du, Jian-Li; Sun, Hong-Yi; Liu, Xian-Ke
Synthetic Communications, 2012 , vol. 42, # 9 p. 1243 - 1258
