3.4-(亚甲基二氧基)苯硼酸合成路线 （共 41 条）
反应条件
1: in tetrahydrofuran T=-75°C; 2.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-75 - 25°C; 13 h; 3: With hydrogenchloride; water in tetrahydrofuran pH=~ 5 - ~ 6;
参考文献
WO2006/34473 A2, ;
Page/Page column 237-238 ;
反应条件
n-butyllithium in tetrahydrofuran; ethyl acetate
参考文献
US2014/128392 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; magnesium in tetrahydrofuran treatment of Grignard reagent (prepd. from bromoderivative) with B(OBu)3 (-78°C), hydrolysis of ester with aq. HCl;
参考文献
Banwell; Cowden; Mackay
Journal of the Chemical Society - Series Chemical Communications, 1994 , # 1 p. 61 - 62
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With magnesium in tetrahydrofuran 19 h; Heatingp; 2: boric acid trimethyl ester in tetrahydrofuran T=-78°C; 3 h; 3: With hydrogenchloride in tetrahydrofuran T=20°C; 15 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 4 p. 1126 - 1136
反应条件
1: chloroform 2: n-butyllithium / tetrahydrofuran; ethyl acetate View Scheme
反应条件
tris-(dibenzylideneacetone)dipalladium(0); i-Pr2NPPh2; water; potassium carbonate in tetrahydrofuran T=65°C; 8 h; Inert atmosphere;
参考文献
Peng, Zhi-Yong; Wang, Jian-Ping; Cheng, Jiang; Xie, Xiao-Min; Zhang, Zhaoguo
Tetrahedron, 2010 , vol. 66, # 42 p. 8238 - 8241
反应条件
1: With (HOCH2)2CMeCH2O-polymer in tetrahydrofuran Cyclization; 2: With Ag(NH3)NO3 in tetrahydrofuran Protodeboronation; 8 h; Heating; Further stages.;
参考文献
Pourbaix, Christelle; Carreaux, Francois; Carboni, Bertrand; Deleuze, Herve
Chemical Communications, 2000 , # 14 p. 1275 - 1276
反应条件
air; Cu(I)-3-methylsalicylate in N,N-dimethyl-formamide T=50°C; Miyaura-Suzuki reaction;
参考文献
Villalobos, Janette M.; Srogl, Jiri; Liebeskind, Lanny S.
Journal of the American Chemical Society, 2007 , vol. 129, # 51 p. 15734 - 15735
反应条件
1: (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin in dichloromethane T=0 - 20°C; 2: 3,4-(methylenedioxy)phenylboronic acid With tetrakis(triphenylphosphine) palladium(0); cesium fluoride in ethylene glycol dimethyl ether T=95°C; Suzuki coupling; 10 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; Title compound not separated from byproducts;
参考文献
Juteau, Helene; Gareau, Yves; Labelle, Marc; Lamontagne, Sonia; Tremblay, Nathalie; Carriere, Marie-Claude; Sawyer, Nicole; Denis, Danielle; Metters, Kathleen M.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 747 - 749
参考文献
Wang, Tao; Zhang, Zhongxing; Meanwell, Nicholas A.; Kadow, John F.; Yin, Zhiwei; Xue, Qiufen May; Regueiro-Ren, Alicia; Matiskella, John D.; Ueda, Yasutsugu
Patent: US2005/90522 A1, 2005 ;
