3,3,3-三氟-2-羟基丙酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Bussche-Huennefeld, Christoph von .; Cescato, Claudio; Seebach, Dieter
Chemische Berichte, 1992 , vol. 125, # 12 p. 2795 - 2802
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Bussche-Huennefeld, Christoph von .; Cescato, Claudio; Seebach, Dieter
Chemische Berichte, 1992 , vol. 125, # 12 p. 2795 - 2802
反应条件
sulfuric acid in ethanol
42 h; Heating / reflux;
参考文献
Central Glass Company, Limited
Patent: US2004/49076 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
sodium tetrahydroborate in diethyl ether
a) ice-cooling, 15 min, b) r.t., 3 h;
参考文献
Bussche-Huennefeld, Christoph von .; Cescato, Claudio; Seebach, Dieter
Chemische Berichte, 1992 , vol. 125, # 12 p. 2795 - 2802
反应条件
1: ethyl magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-propyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-butyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-pentylmagnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: phenyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: ethyl 3,3,3-trifluoro-2-hydroxypropanoate With sodium tetrahydroborate in ethanol
T=20°C; 12 h;
2: C5H8BF3O3 With sulfuric acid in methanol; water
24 h; Heating / reflux;
参考文献
Central Glass Company, Limited
Patent: US2004/49076 A1, 2004 ;
Location in patent: Page 5; 6 ;
