反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 0.5 h, b) RT, 1,5 h
2: aq. HCl / acetone / 6 h / Ambient temperature
3: H2 / 10percent Pd/C / methanol / 517.1 Torr
View Scheme
参考文献
Kaneko; Wong; Doyle; Rose; Bradner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 388 - 392
