2-巯基-S-硫代苯甲酰乙酸合成路线 （共 56 条）
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran T=40°C; 2: carbon disulfide in tetrahydrofuran T=20°C; 2 h; 3: chloroacetic acid With sodium hydrogencarbonate in tetrahydrofuran; water T=90°C; 0.0833333 h;
参考文献
WAYNE STATE UNIVERSITY; DEPARTMENT OF VETERANS AFFAIRS; REGENTS OF THE UNIVERSITY OF MICHIGAN; RISHI, Arun, K.; LARSEN, Scott, D.
Patent: WO2013/33392 A1, 2013 ;
Location in patent: Page/Page column 61-62 ;
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran T=80°C; 2 h; 2: carbon disulfide in tetrahydrofuran T=0°C; 3: monobromoacetic acid in tetrahydrofuran T=20 - 100°C;
参考文献
Wu, De-Qun; Li, Ze-Yong; Li, Cao; Fan, Jian-Jun; Lu, Bo; Chang, Cong; Cheng, Si-Xue; Zhang, Xian-Zheng; Zhuo, Ren-Xi
Pharmaceutical Research, 2010 , vol. 27, # 1 p. 187 - 199
反应条件
1: With sodium carbonate in tetrahydrofuran; water T=20°C; 24 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=2;
参考文献
Chinese Chemical Letters, , vol. 24, # 10 p. 929 - 933
反应条件
1: 76 percent / benzene / standing overnight 2: 95 percent / H2S (gas) / ethanol / 1.) -60 - 50 deg C, 13 hrs., 2.) -15 deg C, overnight View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 17, p. 504 - 510
Zhurnal Organicheskoi Khimii, , vol. 17, # 3 p. 589 - 595
反应条件
1.1: magnesium; iodine / tetrahydrofuran / 12 h / |Reflux 1.2: 12 h / 0 - 20 °C 2.1: sodium carbonate / tetrahydrofuran; water / 24 h / 20 °C 2.2: pH 2 View Scheme
参考文献
Chinese Chemical Letters, , vol. 24, # 10 p. 929 - 933
反应条件
1: 89.1 percent / sulfur / 1 h / Heating 2: 76 percent / benzene / standing overnight 3: 95 percent / H2S (gas) / ethanol / 1.) -60 - 50 deg C, 13 hrs., 2.) -15 deg C, overnight View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 17, p. 504 - 510
Zhurnal Organicheskoi Khimii, , vol. 17, # 3 p. 589 - 595
反应条件
T=50°C; Erhitzen der Reaktionsloesung mit wss. Natrium-chloracetat-Loesung;
参考文献
Arkiv foer Kemi, , vol. 17 A, # 23 p. 2,3
Organic Syntheses, , vol. 42, p. 100
反应条件
1.1: diethyl ether 2.2: |Acidic conditions View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 18 p. 5070 - 5076
反应条件
sulfur; triethylamine 1.) DMSO, 60 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 2 p. 243 - 262
反应条件
alkaline KHS Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 360 - 365
