1: POCl3 / pyridine 2: (hydrolysis) View Scheme

zinc

1,3-bis-(diphenylphosphino)propane; dimethyl zinc; copper (I) cyanide; N-pyrrolidinylnorephedrine in dichloromethane; tert-butyl methyl ether; toluene T=-25°C; 14 h; optical yield given as percent eeenantioselective reaction;

1: POCl3 / pyridine 3: HBr 4: acetic acid 5: (hydrolysis) 6: (catalytic hydrogenation) View Scheme