1,3-二溴-2-(溴甲基)苯合成路线 （共 8 条）
反应条件
1: 67 percent / ethanol; H2O / Heating 2: 90 percent / aq. H2SO4 / 170 °C View Scheme
参考文献
van den Hoogenband, Adri; Lange, Jos H.M.; Iwema-Bakker, Wouter I.; den Hartog, Jack A.J.; van Schaik, Jord; Feenstra, Rolf W.; Terpstra, Jan Willem
Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4361 - 4364
反应条件
1: KOH-solution 2: chromic acid; sulfuric acid View Scheme
参考文献
Olivier
Recueil des Travaux Chimiques des Pays-Bas, 1926 , vol. 45, p. 303
参考文献
Olivier
Recueil des Travaux Chimiques des Pays-Bas, 1926 , vol. 45, p. 303
反应条件
in N,N-dimethyl-formamide T=20°C; 14 h; Inert atmosphere;
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
Location in patent: Page/Page column 69-70 ;
WO 2012/031004 A1
反应条件
in N,N-dimethyl-formamide T=100°C; 1.75 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Patent: US2009/118244 A1, 2009 ;
Location in patent: Page/Page column 15-16 ;
US 20090118244 A1
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy, B.
Patent: WO2012/30990 A1, 2012 ;
Location in patent: Page/Page column 62 ;
WO 2012/030990 A1
反应条件
in ethanol; water
Heating;
参考文献
van den Hoogenband, Adri; Lange, Jos H.M.; Iwema-Bakker, Wouter I.; den Hartog, Jack A.J.; van Schaik, Jord; Feenstra, Rolf W.; Terpstra, Jan Willem
Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4361 - 4364
参考文献
Areschka; Bruylants
Bulletin de la Societe Chimique de France, 1958 , p. 496,498
