5-乙酰基-8-(苄氧基)-2(1H)-喹啉酮合成路线 （共 12 条）
反应条件
N-ethyl-N,N-diisopropylamine in water; acetone 6 - 7 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/123684 A2, 2005 ;
Location in patent: Page/Page column 34 ;
反应条件
sodium carbonate; sodium iodide in water; acetone 24 h; Heating;
参考文献
Amlaiky; Leclerc; Decker; Schwartz
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 341 - 346
反应条件
acetic anhydride T=25 - 40°C; 2 h;
参考文献
WO2008/104781 A1, ;
Page/Page column 38-39 ;
反应条件
1: 75 percent / aluminium chloride / CS2 / 10 h / 80 °C 2: 93 percent / pyridine hydrochloride / 2 h / 200 °C 3: 66 percent / NaI, Na2CO3 / acetone; H2O / 24 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 4 p. 341 - 346
反应条件
1: 69 percent 2: 75 percent / aluminium chloride / CS2 / 10 h / 80 °C 3: 93 percent / pyridine hydrochloride / 2 h / 200 °C 4: 66 percent / NaI, Na2CO3 / acetone; H2O / 24 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 4 p. 341 - 346
反应条件
1: 93 percent / pyridine hydrochloride / 2 h / 200 °C 2: 66 percent / NaI, Na2CO3 / acetone; H2O / 24 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 4 p. 341 - 346
反应条件
1.1: 2.5 h / 70 °C / Cooling with ice 2.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 2.2: 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 2.1: 2.5 h / 70 °C / Cooling with ice 3.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 3.2: 20 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
反应条件
1.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 1.2: 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme
反应条件
1.1: pyridinium tribromide / tetrahydrofuran / 0 °C / Reflux 2.1: (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / tetrahydrofuran / 0.67 h / -55 - -45 °C / Inert atmosphere 2.2: -45 - 0 °C / Inert atmosphere 2.3: 20 °C View Scheme
参考文献
CHIESI FARMACEUTICI S.p.A.; RANCATI, Fabio; RIZZI, Andrea; AMARI, Gabriele; BIAGETTI, Matteo; LINNEY, Ian
Patent: WO2012/168359 A1, 2012 ;
WO 2012/168359 A1
