2-氨基苯并噻唑-6-甲酸合成路线 （共 20 条）
反应条件
bromine in methanol T=-10 - -5°C; 2 h;
参考文献
WANG, YANMING; Wu, Chunying
Patent: US2009/123373 A1, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
hydrogenchloride; water T=100°C; 6 h;
参考文献
Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A
Patent: US2011/319423 A1, 2011 ;
Location in patent: Page/Page column 10 ;
参考文献
Journal of the Chemical Society, , p. 1190
反应条件
sodium hydroxide; bromine in water; acetic acid
反应条件
sodium iodide dichloride T=70°C; 10 h;
参考文献
Telvekar, Vikas N.; Bachhav, Harshal M.; Bairwa, Vinod Kumar
Synlett, 2012 , vol. 23, # 15 p. 2219 - 2222
反应条件
sodium hydroxide in ethanol T=20°C; 4 h;
参考文献
Kitagawa, Hideo; Ozawa, Tomohiro; Takahata, Sho; Iida, Maiko
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4982 - 4986
反应条件
1: bromine; acetic acid / water / 0 - 10 °C 2: hydrogenchloride / water / 2 h / Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 8, # 9 p. 717 - 724
反应条件
hydrogenchloride in water 2 h; Reflux;
参考文献
Letters in Drug Design and Discovery, , vol. 8, # 9 p. 717 - 724
反应条件
1: (i) Br2, AcOH, (ii) aq. Na2CO3 2: aq. HCl / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 27, p. 1533 - 1548
反应条件
1: acetic acid / 3.5 h / 20 °C / Cooling with ice 2: hydrogenchloride; water / 6 h / 100 °C View Scheme
参考文献
EP2354136 A1, ;
EP 2354136 A1
US2011/319423 A1, ;
