(R)-1,2,3,4-四氢喹啉-2-甲酸合成路线 （共 9 条）
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine; (S)-MeO-BIPHEP in toluene
T=20°C; P=37503.8 Torr; 17 h; Inert atmosphereAutoclave; Overall yield = 82 percentChromat.;
参考文献
Maj, Anna M.; Suisse, Isabelle; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron, 2013 , vol. 69, # 44 p. 9322 - 9328
反应条件
1: (R)-[3,3'-(OCH2P(O)(oMePh)2)2-2,2'-diyl-1,1'-biNaphth]AlCl / CH2Cl2; toluene / 64 h / -40 °C
2: H2 / Rh/C / ethyl acetate / 7 h / 760.05 Torr
3: LiOH*H2O; H2O2 / H2O; methanol / 1 h / cooling
4: aq. HCl / 10 h / Heating
View Scheme
参考文献
Takamura; Funabashi; Kanai; Shibasaki
Journal of the American Chemical Society, 2001 , vol. 123, # 28 p. 6801 - 6808
反应条件
1: H2 / Rh/C / ethyl acetate / 7 h / 760.05 Torr
2: LiOH*H2O; H2O2 / H2O; methanol / 1 h / cooling
3: aq. HCl / 10 h / Heating
View Scheme
参考文献
Takamura; Funabashi; Kanai; Shibasaki
Journal of the American Chemical Society, 2001 , vol. 123, # 28 p. 6801 - 6808
反应条件
1: H2 / Rh/C / ethyl acetate / 7 h / 760.05 Torr
2: LiOH*H2O; H2O2 / H2O; methanol / 1 h / cooling
3: aq. HCl / 10 h / Heating
View Scheme
参考文献
Takamura; Funabashi; Kanai; Shibasaki
Journal of the American Chemical Society, 2001 , vol. 123, # 28 p. 6801 - 6808
反应条件
1: LiOH*H2O; H2O2 / H2O; methanol / 1 h / cooling
2: aq. HCl / 10 h / Heating
View Scheme
参考文献
Takamura; Funabashi; Kanai; Shibasaki
Journal of the American Chemical Society, 2001 , vol. 123, # 28 p. 6801 - 6808
反应条件
hydrogenchloride
Hydrolysis; 10 h; Heating;
参考文献
Takamura, Masahiro; Funabashi, Ken; Kanai, Motomu; Shibasaki, Masakatsu
Journal of the American Chemical Society, 2000 , vol. 122, # 26 p. 6327 - 6328
反应条件
1: H2 / PtO2 / methanol
2: SOCl2
View Scheme
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
反应条件
1: SOCl2
View Scheme
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
参考文献
Katayama, Seiji; Ae, Nobuyuki; Nagata, Ryu
Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4295 - 4299
