2-(3-氯丙氧基)-1-甲氧基-4-硝基苯合成路线 （共 5 条）
反应条件
sodium hydride in N,N-dimethyl-formamide; acetonitrile T=60°C; 3 h;
参考文献
Mutai, Kiyoshi; Kobayashi, Keiji; Yokoyama, Kenji
Tetrahedron, 1984 , vol. 40, # 10 p. 1755 - 1760
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 2 h; Product distribution / selectivity;
参考文献
US2005/43537 A1, ;
Page/Page column 3; 6-7 ;
反应条件
1: sodium iodide / ethylene glycol dimethyl ether 2: hydrogen; palladium on activated charcoal / isopropyl alcohol 3: orthoformic acid triethyl ester / isopropyl alcohol 4: trichlorophosphate / sulfolane / 16 h / 80 - 105 °C View Scheme
参考文献
Withbroe, Gregory J; Seadeek, Chris; Girard, Kevin P; Guinness, Steven M; Vanderplas, Brian C; Vaidyanathan, Rajappa
Organic Process Research and Development, 2013 , vol. 17, # 3 p. 500 - 504
反应条件
sodium iodide in ethylene glycol dimethyl ether
8 h; Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: US2005/43537 A1, 2005 ;
Location in patent: Page/Page column 3; 13-14 ;
反应条件
1: sodium iodide / ethylene glycol dimethyl ether
2: hydrogen; palladium on activated charcoal / isopropyl alcohol
View Scheme
参考文献
Withbroe, Gregory J; Seadeek, Chris; Girard, Kevin P; Guinness, Steven M; Vanderplas, Brian C; Vaidyanathan, Rajappa
Organic Process Research and Development, 2013 , vol. 17, # 3 p. 500 - 504
