5,5,8,8-四甲基-5,6,7,8-四氢-2-萘甲醛合成路线 （共 10 条）
反应条件
ammonium cerium(IV) nitrate; acetic acid in water
T=100°C; 1 h;
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
ammonium cerium(IV) nitrate; acetic acid
T=100°C; 0.25 h;
参考文献
Dawson; Hobbs; Derdzinski; Chao; Frenking; Loew; Jetten; Napoli; Williams; Sani; Wille Jr.; Schiff
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1504 - 1517
反应条件
in dichloromethane
T=0 - 20°C; 1.08333 h;
参考文献
Merck Patent Gesellschaft MIT Beschrankter Haftung
Patent: US2012/252815 A1, 2012 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 91 percent / aluminum chloride / CH2Cl2 / 0.5 h / 20 °C
2: 78 percent / aq. (NH4)2Ce(NO3)6 / acetic acid / 1 h / 20 °C
View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
参考文献
Eustache; Bernardon; Shroot
Tetrahedron Letters, 1988 , vol. 29, # 35 p. 4409 - 4410
反应条件
1: 71 percent / AlCl3 / 1 h / 0 °C
2: 78 percent / ceric ammonium nitrite, AcOH / H2O / 1 h / 100 °C
View Scheme
参考文献
Tashima, Toshihiko; Kagechika, Hiroyuki; Tsuji, Motonori; Fukasawa, Hiroshi; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1805 - 1813
反应条件
1: 59 percent / AlCl3 / 0.33 h / 5 - 10 °C
2: 1) Mg, CH3I / 1) THF, 50-55 deg C, 30 min, 2) THF, -20 deg C to 0 deg C, 1 h
View Scheme
参考文献
Dawson; Hobbs; Derdzinski; Chao; Frenking; Loew; Jetten; Napoli; Williams; Sani; Wille Jr.; Schiff
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1504 - 1517
反应条件
1: hydrogenchloride / water / 48 h / 25 °C
2: AlCl3, aluminium chloride / 24 h / 25 °C / |Inert atmosphere
3: ammonium cerium (IV) nitrate / water; acetic acid / 2.25 h / 100 °C
View Scheme
参考文献
Ling, Xiaoxi; Masson, Eric
Organic Letters, 2012 , vol. 14, # 18 p. 4866 - 4869
反应条件
magnesium; methyl iodide
1) THF, 50-55 deg C, 30 min, 2) THF, -20 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Dawson; Hobbs; Derdzinski; Chao; Frenking; Loew; Jetten; Napoli; Williams; Sani; Wille Jr.; Schiff
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1504 - 1517
反应条件
tert.-butyl lithium
1.) THF, pentane, -78 deg C, 15 min, 2.) THF, pentane, a) -78 deg C, 30 min, b) 0 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Yu; Ostrowski; Chen; Reczek; Mansuri; Starrett Jr.
Synthetic Communications, 1995 , vol. 25, # 18 p. 2819 - 2827
