反应条件
2: 92 percent / 2,6-lutidine / CH2Cl2 / 1 h / -78 °C 4: 94 percent / DMAP, NEt3 / CH2Cl2 / 2 h / 20 °C 5: 1) Me3SiCl, NEt3, LDA, 2) aq. HCl / 1) THF, -78 deg C, 1 h, then 20 deg C, 1 h, then 60 deg C, 2 h 6: diethyl ether / 0 °C 7: 80 percent / DIBAL / diethyl ether / 0.33 h / -98 °C 9: 99 percent / H2O2, LiOH / tetrahydrofuran; H2O / 20 h / 20 °C 10: 87 percent / PhSO2Cl, pyridine / 16 h / -20 °C 11: 100 percent / aq. HF / acetonitrile / 2 h / 20 °C 12: H2 / (Ph3P)3RhCl / benzene / 2 h / 20 °C / 760 Torr View Scheme
参考文献
Paterson; Hulme
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7513 - 7516
