反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 25 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / |Inert atmosphere
2.2: -78 - 25 °C / |Inert atmosphere
3.1: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C
View Scheme
参考文献
Gore, Vivek; Patel, Pranav; Chang, Chih-Tsung; Sivendran, Sashikala; Kang, Namin; Ouedraogo, Yannick P.; Gravel, Sylvie; Powell, William S.; Rokach, Joshua
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3725 - 3732