3,4-二氢-6-甲基-2H-1-苯并吡喃-2-酮合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Griffiths, D. Vaughan; Wilcox, Geoffrey
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 431 - 436
反应条件
1: LiAlH4 / diethyl ether 2: aq. NaOH View Scheme
参考文献
Billman; Tonnis
Journal of pharmaceutical sciences, 1971 , vol. 60, # 8 p. 1188 - 1192
反应条件
1: LiAlH4 / diethyl ether 2: aq. NaOH 3: Pb(OAc)4, Py View Scheme
参考文献
Billman; Tonnis
Journal of pharmaceutical sciences, 1971 , vol. 60, # 8 p. 1188 - 1192
反应条件
hydrogen; 20 Pd(OH)2/C in tetrahydrofuran
T=50°C; P=4654.46 Torr; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2010/210635 A1, 2010 ;
Location in patent: Page/Page column 53 ;
反应条件
4-(N,N-dimethlyamino)pyridine; 4-mesityl-3-(4-methoxyphenyl)-1-phenyl-4H-1,2,4-triazol-1-ium perchlorate in ethyl acetate
T=80°C; 15 h; Inert atmosphere;
参考文献
Zeitler, Kirsten; Rose, Christopher A.
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1759 - 1762
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in benzene
10 h; Heating;
参考文献
Moorthy, Jarugu Narasimha; Singhal, Nidhi; Mal, Prasenjit
Tetrahedron Letters, 2004 , vol. 45, # 2 p. 309 - 312
反应条件
1: With Oxonereg;; (ethylenedinitrilo)tetraacetic acid disodium salt; sodium hydrogencarbonate in acetonitrile
T=20°C; Oxidation; 2 h;
2: With potassium hydroxide
Hydrolysis; Heating;
3: With toluene-4-sulfonic acid in benzene
Cyclization; 2 h; Heating; Further stages. Title compound not separated from byproducts.;
参考文献
Yang, Dan; Wong, Man-Kin; Yan, Zheng
Journal of Organic Chemistry, 2000 , vol. 65, # 13 p. 4179 - 4184
反应条件
boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene in trifluoroacetic acid
T=30°C; 12 h;
参考文献
Gu, Yonghong; Xue, Kun
Tetrahedron Letters, 2010 , vol. 51, # 1 p. 192 - 196
反应条件
lithium hydride
T=188°C; 15 h; Yield given;
参考文献
Pickett, James E.; Van Dort, Paul C.
Tetrahedron Letters, 1992 , vol. 33, # 9 p. 1161 - 1164
反应条件
water; formic acid in 1,4-dioxane
T=25.2°C; var. acid catalysts, var. pH, catalytic constants, ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Lamaty, Gerard; Lorente, Philippe; Moreau, Claude
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2651 - 2656
